Conference

Heidelberg Conference on Cancer Neuroscience 2023

1st Heidelberg Conference on Cancer Neuroscience

July 18-19, 2023

Venue: German Cancer Research Center (DKFZ), Communication Center,

Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Conference Program

July, 18th 2023
09:00 – 09:30	Welcome and Introduction	Frank Winkler, MD (Heidelberg University, Medical Faculty, German Cancer Research Center (DKFZ)) Wolfgang Wick, MD (Heidelberg University, Medical Faculty, German Cancer Research Center (DKFZ))
09:30 – 10:30	INSTRUCTIONS FROM NEURODEVELOPMENT AND THE NORMAL NERVOUS SYSTEM	Chairs: Stefan Pfister, MD (Heidelberg University, Medical Faculty, German Cancer Research Center (DKFZ)), Ana Martin-Villalba, MD, PhD (German Cancer Research Center (DKFZ), Heidelberg)
09:30 – 09:45	Neuron-glial interactions regulating brain development, plasticity and cancer	Michelle Monje, MD, PhD (Stanford University, California)
09:45 – 10:00	How the Peripheral Nervous System governs tissue development, homeostasis, and plasticity: lessons for Cancer Neuroscience	Frank Winkler, MD (Heidelberg University, Medical Faculty, German Cancer Research Center (DKFZ))
10:00 – 10:20	Cellular development and evolution of the human brain	Henrik Kaessmann, PhD (Heidelberg University, Medical Faculty)
10:20 – 10:30	Neuroblastoma arises in early fetal development and its evolutionary duration predicts outcome	Verena Körber, PhD (German Cancer Research Center (DKFZ)) – Abstract No 52
10:30 – 10:45	Coffee Break
10:45 – 12:55	BRAIN CANCER NEUROSCIENCE	Chairs: Thomas Kuner, MD (Heidelberg University, Medical Faculty), Felix Sahm, MD (Heidelberg University, Medical Faculty, German Cancer Research Center (DKFZ))
10:45 – 11:05	Paracrine neural influences in gliomagenesis	Michelle Monje, MD, PhD (Stanford University, California)
11:05 – 11:15	Synaptic interactions between neurons and glioma cells	Varun Venkataramani, MD, PhD (Heidelberg University, Medical Faculty, German Cancer Research Center (DKFZ))
11:15 – 11:35	Glioblastoma remodeling of neural circuits in the human brain decreases survival	Shawn Hervey-Jumper, MD (University of California, San Francisco)
11:35 – 11:55	Decoding neuron-glioma crosstalk	Benjamin Deneen, PhD (Baylor College of Medicine, Housten, Texas)
11:55 – 12:05	Targeting Tumor Microtube-mediated glioblastoma networks	Sophie Weil, MD (Heidelberg University, Medical Faculty, German Cancer Research Center (DKFZ))
12:05 – 12:15	Pacemaker-like hub cells in glioblastoma	David Hausmann, MD (Heidelberg University, Medical Faculty, German Cancer Research Center (DKFZ))
12:15 – 12:25	Conditional expression and activation of designer receptors exclusively activated by designer drugs (DREADD) reveals novel impact of neuron-tumor communications on brain tumor progression	Daisuke Kawauchi, PhD (National Center of Neurology and Psychiatry) – Abstract No 10
12:25 – 12:35	Rewiring of the promoter-enhancer interactome and regulatory landscape in glioblastoma orchestrates gene expression underlying neurogliomal synaptic communication	Silvia Remeseiro, PhD (Umeå Centre for Molecular Medicine (UCMM), Wallenberg Centre for Molecular Medicine (WCMM), Umeå University, Sweden) – Abstract No 23
12:35 – 12:45	Cancer-neuronal cross talk in Glioblastoma: how neurons sustain tumor progression	Chiara Saulle (Laboratory of Pharmacology and Brain Pathology, IRCCS Humanitas Research Center Rozzano, Milan, Italy) – Abstract No 70
12:45-12:55	Mapping the rules of glioblastoma with integrated single cell and spatial genomics	Omer Bayraktar, PhD (Wellcome Sanger Institute, Hinxton, United Kingdom) – Abstract No 72
12:55 – 13:45	Lunch
13:45 – 15:45	EXTRACRANIAL CANCER NEUROSCIENCE	Chairs: Rohini Kuner, PhD (Heidelberg University, Medical Faculty), Erica Sloan, PhD (Monash University, Melbourne)
13:45 – 14:05	Clinical opportunities of translation in extracranial Cancer Neuroscience	Ekin Demir, MD, PhD (TU Munich, Medical Faculty)
14:05 – 14:25	Cancer and Brain: An addictive long distance relationship	Claire Magnon, PhD (INSERM, Paris)
14:25 – 14:45	Neuro-cancer interactions in head and neck cancer	Moran Amit, MD, PhD (MD Anderson, Houston, Texas)
14:45 – 15:05	Molecular targeted therapies for Cancer Neuroscience: learning from general oncology	Sonja Loges, MD, PhD (Heidelberg University, Medical Faculty Mannheim, German Cancer Research Center (DKFZ))
15:05 – 15:15	Unraveling the hidden dance: Schwann Cells’ role in shaping axonal remodeling during pancreatic cancer progression	Sophie Chauvet, MD, PhD, (Aix Marseille Univ, CNRS, IBDM, France) – Abstract No 20
15:15 – 15:25	Nerve guidance in cancer: a new role for Netrin-1	Hiba Haidra (Aix Marseille Univ, CNRS, IBDM, France) – Abstract No 31
15:25 – 15:35	Single cell atlas of PDAC innervating neurons	Vera Thiel, PhD candidate (German Cancer Research Center (DKFZ), Heidelberg))
15:35 – 16:00	Coffee Break
16:00 – 17:00	METASTASIS CANCER NEUROSCIENCE	Chairs: Humsa Venkatesh, PhD (Harvard University, Boston, Massachusetts), Moran Amit, MD, PhD (MD Anderson, Houston, Texas)
16:00 – 16:20	Neural-Activity Dependent Growth of Brain Metastases	Humsa Venkatesh, PhD (Harvard University, Boston, Massachusetts)
16:20 – 16:30	Neuron-tumor cell synapses drive brain metastases	Matthia Karreman, PhD (Heidelberg University, Medical Faculty, German Cancer Research Center (DKFZ))
16:30 – 16:40	Machine learning identifies experimental brain metastasis subtypes based on their influence on neural circuit	Mariam Al-Masmudi Martín, PhD (Spanish National Cancer Research Center (CNIO), Madrid, Spain) – Abstract No 16
16:40 – 18:15	NEURO-IMMUNO-ONCOLOGY	Chairs: Lucas Schirmer, MD (Heidelberg University, Medical Faculty Mannheim), Adelheid Cerwenka, PhD (Heidelberg University, Medical Faculty Mannheim)
16:40-17:00	FMRP is a master regulator of the immunosuppressive tumor microenvironment	Douglas Hanahan, PhD (EPFL, Lausanne)
17:00 – 17:20	Nociceptor neuron impact cancer immunosurveillance	Sebastien Talbot, PhD (Queen’s University, Kingston, Ontario)
17:20 – 17:40	Neuron-immune axis support of glioma growth	David Gutmann, MD, PhD (Washington University in St. Louis, Missouri)
17:40 – 18:00	T cell therapy of brain tumors	Michael Platten, MD (Heidelberg University, Medical Faculty Mannheim, German Cancer Research Center (DKFZ))
18:00 – 18:15	A novel immunotherapeutic strategy for glioblastoma	Agnieszka Chryplewicz (Swiss Institute for Experimental Cancer Research (ISREC), Lausanne, Switzerland) – Abstract No 3
From 19:30	Conference Dinner

July, 19th 2023
09:00 – 10:35	Effects of Cancer and Cancer Therapies on the Nervous System	Chairs: Wolfgang Wick, MD (Heidelberg University, Medical Faculty, German Cancer Research Center (DKFZ)), Christoph Michalski, MD (Ulm University, Heidelberg University, Medical Faculty)
09:00 – 09:15	Neurobiological underpinnings of cancer therapy-related cognitive impairment	Michelle Monje, MD, PhD (Stanford University, California)
09:15 – 09:35	Getting on my nerves: cancer pain	Rohini Kuner, PhD (Heidelberg University, Medical Faculty)
09:35 – 09:55	Daily-life and neural network research: Prospects for cancer neuroscience	Heike Tost, MD, PhD (Heidelberg University, Medical Faculty Mannheim)
09:55 – 10:15	Cancer therapy induced neurodegeneration and neuroprotective strategies	Jorg Dietrich, MD, PhD (Harvard University, Boston, Massachusetts)
10:15 – 10:25	Colon cancer driven systemic sensory neuronal dysfunction in orthotopic mouse models	Mihály Balogh, PhD (University of Groningen, Netherlands) – Abstract No 24
10:25 – 10:35	Delayed STING-independent type-I interferon response after cranial irradiation drives microglia into senescence	Alejandro Lastra Romero, (Karolinska Institutet, Sweden) – Abstract No 33
10:35 – 10:45	Coffee Break
10:45 – 11:45	Towards Neuroscience-instructed Cancer Therapies	Chairs: Frank Winkler, MD (Heidelberg University, Medical Faculty, German Cancer Research Center (DKFZ)), Sandro Krieg, MD (TU Munich, Heidelberg University, Medical Faculty)
10:45 – 11:05	General considerations & early clinical trials for brain cancer	Wolfgang Wick, MD (Heidelberg University, Medical Faculty, German Cancer Research Center (DKFZ))
11:05 – 11:25	Can sympathetic neural signalling be targeted to prevent relapse after cancer treatment?	Erica Sloan, PhD (Monash University, Melbourne)
11:25 – 11:35	Imaging biomarkers of the CNS and PNS	Michael Breckwoldt, MD, PhD (Heidelberg University, Medical Faculty), German Cancer Research Center (DKFZ))
11:35 – 11:45	GLUGLIO – A phase Ib/II randomized drug repurposing trial of glutamate signaling inhibitors in combination with chemoradiotherapy in patients with newly diagnosed glioblastoma	Hans-Georg Wirsching, PhD (University Hospital and University of Zurich, Switzerland) – Abstract No 54
11:45 – 12:30	Poster Session 1 (Topics 1-4)
12:30 – 13:15	Lunch
13:15 – 14:45	Technological and Structural Developments for Cancer Neuroscience	Chairs: Sinem Saka, PhD (EMBL, Heidelberg), Varun Venkataramani, MD, PhD (Heidelberg University, Medical Faculty, German Cancer Research Center (DKFZ))
13:15 – 13:35	Deciphering the neuron-tumor cell dialogue with single cell RNA-sequencing	Mariella Filbin, MD, PhD (Harvard University, Boston, Massachusetts)
13:35 – 13:50	Targeted ultrastructure of neuron-tumor interfaces	Thomas Kuner, MD (Heidelberg University, Medical Faculty)
13:50 – 14:05	Recording the physiological history of cells with chemical labeling	Kai Johnsson, PhD (MPI for Medical Research, Heidelberg)
14:05 – 14:15	Region-selective spatial transcriptomics for Cancer Neuroscience	Sinem Saka, PhD (EMBL, Heidelberg)
14:15 – 14:30	Data science & Mathematical modeling	Anna Marciniak-Czochra, PhD (Heidelberg University, Medical Faculty)
14:30 – 14:45	In-vivo imaging approaches for Cancer Neuroscience	Robert Prevedel, PhD (EMBL, Heidelberg)
14:45-15:05	Publishing in Nature (in Cancer Neuroscience and beyond): how we work and how decisions are reached	Barbara Marte, Senior Editor, Nature (London, UK)
15:05 – 16:15	Workshops
15:05 – 16:15	How do we advance Cancer Neuroscience?
	Development of technologies, models and data science	Varun Venkataramani, MD, PhD (Heidelberg University, Medical Faculty, German Cancer Research Center (DKFZ)) Mariella Filbin, MD, PhD (Harvard University, Boston, Massachusetts) Marciniak-Czochra, PhD (Heidelberg University, Medical Faculty) Judith Zaugg, PhD (EMBL, Heidelberg)
15:45-16:15	Career development	Frank Winkler, MD (Heidelberg University, Medical Faculty, German Cancer Research Center (DKFZ)) Wolfgang Wick, MD (Heidelberg University, Medical Faculty), German Cancer Research Center (DKFZ)) Humsa Venkatesh, PhD (Harvard University, Boston, Massachusetts) Vera Thiel, PhD candidate (German Cancer Research Center (DKFZ), Heidelberg))
16:15 – 17:00	Poster Session 2 (Topics 5-8) & Coffee Break
17:00 – 18:00	Panel Discussion
17:00 – 18:00	Where do we stand – what do we need for future development of the field? With Michelle Monje, MD, PhD (Stanford University, California) Douglas Hanahan, PhD (EPFL, Lausanne) Ekin Demir, MD, PhD (TU Munich, Medical Faculty) Sebastien Talbot, PhD (Queen’s University, Kingston, Ontario) Shawn Hervey-Jumper, MD (University of California, San Francisco) Frank Winkler, MD (Heidelberg University, Medical Faculty, German Cancer Research Center (DKFZ)) Wolfgang Wick, MD (Heidelberg University, Medical Faculty), German Cancer Research Center (DKFZ)) Sonja Loges, MD, PhD (Heidelberg University, Medical Faculty Mannheim, German Cancer Research Center (DKFZ))	Moderation Varun Venkataramani, MD, PhD (Heidelberg University, Medical Faculty), German Cancer Research Center (DKFZ))

Heidelberg Conference on Cancer Neuroscience 2023

Conference Program

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